The present treatment cocktail represents a dual mode topical treatment for the skin disease psoriasis. The composition contains at least an Analgesic Agent and a Drying Agent as selected from the group disclosed herein. The agents heal psoriatic plaques by promoting the exfoliation of existing psoriatic plaques and preventing additional plaque formation. Further, the dual mode action is useful to reduce the pain and itching associated with such plaques which results in less irritation and shorter outbreaks.