A method of synthesis of a 2-substituted adenosine of formula I which
comprises converting a compound of formula II to a compound of formula
(I), wherein: R is C 1-6 alkoxy (straight or branched), a phenoxy group
(unsubstituted, or mono-, or di-substituted by halo, amino, CF3-, cyano,
nitro, C 1-6 alkyl, or C 1-6 alkoxy), a benzoyl group (unsubstituted, or
mono-, or di-substituted by halo, amino, CF3-, cyano, nitro, C1_6 alkyl,
or C1_6 alkoxy), or a benzoyl group (unsubstituted, or mono-, or
di-substituted by halo, amino, CF3-, cyano, nitro, C 1-6 alkyl, or C 1-6
alkoxy); R'.dbd.H, or a protecting group.