The compounds of the general formula (I) in which X is represents two hydrogen atoms, a .pi.-bond, oxygen or methylene: R2 is a C.sub.6-C.sub.12 aryl, or arylalkyl residue: R3 is hydrogen, 2-hydroxyethyl or 2-aminoethyl are useful for the treatment of pathologies mediated by vanilloid receptors type I. ##STR00001##

 
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> Combretastatin analogs with tubulin binding activity

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