A blood component collection system with data manipulation and optimization capabilities. The system comprises a central database, a data manipulation device, and a communication subsystem connected to the central database and the data manipulation device, and one or more extracorporeal blood processing machines. The central database maintains records of total donation volumes contributed by a donor during selected time periods as communicated by the blood processing machine and as determined by the data manipulation device. The records comprise a total red blood cell donation volume and a total plasma donation volume.