A method and system for automatic diagnosis of possible brain disease is based on at least one brain scan image of a patient containing at least one feature of interest and a corresponding result of a medical profile analysis of the patient. A database containing parameters associated with at least one feature of a plurality of brain scan images each compiled from respective patient data and inserted into the database is searched so as to extract from the database a set of respective parameters each associated with the at least one feature and wherein in respect of each feature at least one of the corresponding parameters is indicative of a brain disease profile. The set of respective parameters is analyzed to determine a statistically significant brain disease profile which fits the patient based on the at least one feature of interest of the patient's brain scan image.