The present invention is directed to methods of using pro-NAD agents
capable of enhancing the dermal and epidermal skin cell NAD content.
These pro-NAD agents may be administered topically, orally, or
parenterally to enhance DNA repair and other protective responses to DNA
damage. The invention further relates to pharmaceutical compositions
comprising pro-NAD agents that effectively elevate intracellular NAD
content. Finally, the invention relates to the method of using the
pro-NAD agents to treat disorders such as sunburn and other skin
deterioration that results from DNA damage in skin cells.