A MALDI ion source includes a sample plate for receiving a sample, a laser
for producing laser radiation to ionize the sample, a first optical
element arranged so as to direct the laser radiation along a first
optical path toward the target area, and a second optical element
arranged along the first optical path to focus the laser radiation onto
the target area. The first and second optical elements are arranged that
light that is reflected from the target area travels along the first
optical path through the first and second optical elements, the first
optical element reflecting the laser radiation along a first direction
and transmitting the light reflected from the target area that has
traversed the first optical path in a second direction. An imaging device
for viewing the plate surface may be arranged to receive the light that
has been reflected from the target area and has traversed the first
optical path through the first and second optical elements.