A low-concentration formulation of an active enamel substance, such as an
enamel matrix, enamel matrix derivative and/or an enamel matrix protein,
is intended to be used as a therapeutic, as a prophylactic and/or as a
cosmetic agent. The active enamel substance is incorporated into a
polymeric matrix, which is either suitable for cellular in-growth, or is
cell-occlusive, so that it is released by degradation of the polymeric
matrix, by enzymatic action and/or by diffusion. A new pharmaceutical
and/or cosmetic formulation of an active enamel substance is provided at
a lower total concentration within the formulation, wherein a spatial
and/or selective regulation of release of said active enamel substance
permits a greater percentage of the active enamel substance to be
released at the time of appropriate cellular activity.