Provided is an electrochemical sensor strip having circuits comprising electrodes in an electrode region connected to contact pads in a contact region by conductive traces wherein the electrode region is off-set from the contact region in both an x direction parallel to the length of the sensor strip and a y direction parallel to the width of the sensor strip. Also provided is a an electrochemical sensor strip having a backing material, an active portion laminated to a portion of the backing material, the active portion comprising a substrate, a circuit comprising electrodes in an electrode region connected to contact pads in a contact region by conductive traces wherein the electrode region is off-set from the contact region in both an x direction parallel to the length of the sensor strip and a y direction parallel to the width of the sensor strip, a polymeric layer comprising a channel-forming material over the electrodes, and a hydrophilic layer over the channel-forming material.