The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I ##STR00001## The present invention also provides methods for the use thereof to inhibit .beta.-secretase (BACE) and treat .beta.-amyloid deposits and neurofibrillary tangles.

 
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< Phenylcarboxylate beta-secretase inhibitors for the treatment of alzheimer's disease

> Engineered enzymes and uses thereof
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