Compounds of formula I, wherein R.sub.1-R.sub.9 and n are defined herein, and pharmaceutical compositions and kits containing these compounds are provided. ##STR00001## Also provided are methods of inducing contraception, providing hormone replacement therapy, treating cycle-related symptoms, or treating or preventing benign or malignant neoplastic disease using the compounds of formula I or formula II, wherein R.sub.3-R.sub.5, R.sub.10, and R.sub.11 are defined herein. ##STR00002##