The present invention provides a bioactive, small-diameter (typically less
than 6 mm in internal diameter) vascular graft prosthesis, and is a
textile conduit preferably manufactured using a novel electrospinning
perfusion methodology. One preferred embodiment is a nanofibrous
biocomposite textile conduit which comprises a prepared liquid admixture
of polyester (Dacron), a biodurable implantable synthetic polymer, and
Type IV collagen, an extracellular matrix protein. This prepared
admixture and blending of diverse fibrous matter is utilized in a novel
electrospinning perfusion process to form a small-diameter (less than 6
mm) fabricated textile conduit, a discrete article of manufacture, which
then serves as an antecedent tangible workpiece for a subsequently-made
prosthetic vascular graft construct.