A system and method for controlling inflow of fluid into a production string. In aspects, the invention provides a downhole sand screen and inflow control device with a gas or water shut-off feature that can be operated mechanically or hydraulically from the surface of the well. The device also preferably includes a bypass feature that allows the inflow control device to be closed or bypassed via shifting of a sleeve. In embodiments, the flow control device can be adaptive to changes in wellbore conditions such as chemical make-up, fluid density and temperature. Exemplary adaptive inflow control devices include devices configured to control flow in response to changes in gas/oil ratio, water/oil ratio, fluid density and/or the operating temperature of the inflow control device. In other aspects of the present invention, inflow control devices are utilized to control the flow of commingled fluids drained via two or more wellbores.