This disclosure provides the nucleic acid and protein sequences of novel P450 oxygenases that utilize, at least, taxoid substrates, including taxadiene isomers. The disclosed oxygenases, such as a taxoid 5.alpha.-hydroxylase, hydroxylate, at least, the C5 position of a taxoid. Also provided are methods of introducing oxygen at the C5 position of a taxoid and methods of producing the anti-cancer drug, paclitaxel (also known as Taxol.TM.), and other taxoids, such as paclitaxel intermediates.

 
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< Method for producing heart-specific fluorescence of non-human eukaryotic animals

> Fluorescent through-bond energy transfer cassettes based on xanthine and pyronin derivatives

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