This invention provides methods for imaging and/or treating a tumor in a
subject which comprise administering to the subject an amount of a
radiolabeled antibody effective to image and/or treat the tumor, where
the radiolabeled antibody binds to a cellular component released by dying
tumor cells. This invention also provides methods for imaging and/or
treating melanin-containing melanomas in a subject which comprise
administering to the subject an amount of a radiolabeled anti-melanin
antibody effective to image and/or treat the melanoma. The invention also
provides compositions and methods of making compositions comprising
radiolabeled antibodies for imaging and treating tumors, including
melanin-containing melanomas.