8-Hydroxy-1-oxo-tetrahydropyrrolopyrazine compounds are inhibitors of HIV
integrase and inhibitors of HIV replication. More particularly, the
compounds are of Formula (I): wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4,
R.sup.5 and R.sup.6 are defined herein. The compounds are useful in the
prevention and treatment of infection by ITV and in the prevention, delay
in the onset, and treatment of AIDS. The compounds are employed against
HIV infection and AIDS as compounds per se or in the form of
pharmaceutically acceptable salts. The compounds and their salts can be
employed as ingredients in pharmaceutical compositions, optionally in
combination with other antivirals, immunomodulators, antibiotics or
vaccines. Methods of preventing, treating or delaying the onset of AIDS
and methods of preventing or treating infection by HIV are described.
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