A system and method are provided for integrated registration of images, the system including a processor, a first registration portion for performing rough registration of an image, a first segmentation portion for performing segmentation of an object of interest in the image, a second registration portion for performing fine registration of the image, and a second segmentation portion for performing segmentation of structures of the object of interest in the image; and the method including receiving a sequence of images, selecting an image from the sequence, cropping a region of interest (ROI) from the selected image, performing rough registration of the cropped ROI, performing segmentation of an object of interest from the rough registered ROI, performing fine registration of the ROI, and performing segmentation of structures of the object of interest from the fine registered ROI.