An exemplary method of reducing the volume of a stomach comprises providing an adhesive applier and a biocompatible adhesive. The exemplary method further comprises introducing at least a portion of the adhesive applier into the stomach and dispensing the adhesive through the adhesive applier into the stomach. The adhesive may be applied between the submucosa and muscle layers of the stomach to reduce the volume of the stomach. The adhesive may alternatively be applied in layers onto the inner surface of the stomach. Alternatively, a non-expandable member may be introduced into the stomach, and an adhesive may be used to secure the non-expandable member to the stomach. Such uses may provide a treatment for morbid obesity. An adhesive may also be used to provide flow restriction, such as by injecting the adhesive between the submucosa and muscle layers of a cardia or rectum.