A method of distributed control of train throttle and braking includes transmitting an instruction to a remote power unit to apply at least one acceleration to the train at a future time; receiving the instruction; transmitting a confirmation that the remote power unit is armed to execute the instruction to a lead power unit; and computing a profile describing at least one acceleration to be applied to the train as it travels over a predetermined route. The computation is determined at least in part on whether or not the confirmation has been received by the lead power unit. The instructions may be contained in a profile which optimizes fuel consumption, emissions, and/or trip time. The accelerations may be carried out by direct control or by prompting an operator. In another aspect, the confirmed instructions may be used to ensure braking in accordance with a predetermined braking curve.