The present invention describes a method that is operative within a clinical environment in which real-time locations of personnel and resources are tracked. The method begins in association with entry of a patient into the clinical environment, such as when a patient is in transit, or has been admitted, to an emergency room or to a hospital. In response, a given care guideline is identified. Using the care guideline, a set of one or more process rules, and information associated with at least one "encounter," the system generates a patient-specific care protocol; the protocol includes a set of steps through which the patient is expected to proceed while in the clinical environment. An encounter occurs when two or more of objects (e.g., the patient, clinical personnel, and a clinical resource) are in a given physical proximity for a given time period at determined by the at least one process rule. According to the method, at least one event that occurs during at least a first step of the patient-specific care protocol is then monitored. Using information generated by the monitoring step and at least one process rule, the system then determines whether the patient moves to a next step in the patient-specific care protocol.