The present invention relates to new piperidyl- or piperazinyl-substituted dihydro-2H-1-benzopyran derivatives having the formula (I) ##STR00001## wherein X is N; Y is NR.sub.2CH.sub.2, CH.sub.2NR.sub.2, NR.sub.2CO, CONR.sub.2, NR.sub.2SO.sub.2 or NR.sub.2CONR.sub.2 wherein R.sub.2 is H or C.sub.1-C.sub.6 alkyl; R.sub.1 is H, C.sub.1-C.sub.6 alkyl or C.sub.3-C.sub.6 cycloalkyl; R.sub.3 is C.sub.1-C.sub.6 alkyl, C.sub.3-C.sub.6 cycoalkyl or (CH.sub.2).sub.n-aryl, wherein aryl is a heteromatic ring containing one or two heteroatoms selected from N, O and S and which may be mono- or di-substituted with R.sub.4 and/or R.sub.5; and n is 0-4; as (R)-enantiomers, (S)-enantiomers or racemates in the form of a free base or a pharmaceutically acceptable salt or solvate thereof, a process for their preparation, pharmaceutical compositions containing said therapeutically active compounds and to the use of said active compounds.

 
Web www.patentalert.com

< 2-(phenoxymethyl)-and 2-(phenylthiomethyl)-morpholine derivatives for use as selective norepinephrine reuptake inhibitors

> Monoclonal antibody specific for PPAR gamma, hydridoma cell line producing the same, and method for detecting regulator related to diseases, including inflammation, cancer and metabolic diseases, using the same

~ 00441