An air decontamination system including a sealed room to hold at least one person and the sealed room having an air inlet. The system further including a vacuum unit to create a negative pressure within the sealed room, by suctioning air through the air inlet into the sealed room and then from the sealed room into an inlet of the vacuum unit. The system still further including a work surface disposed in the sealed room at a predetermined height above a floor of the sealed room and the work surface to receive at least one mail piece and the air to be suctioned downwardly over the at least one mail piece and the work surface; and a filter unit to filter the air as the air is drawn out of the sealed room.