There are provided a knee joint prosthesis for a bi-compartmental knee replacement and surgical devices thereof, wherein the knee joint prosthesis for the bi-compartmental knee replacement, which is performed on a patient with degenerative arthritis at any one of an inside compartment and an outside compartment of the knee and between the femur and the patella, is configured to position a femoral component at the inside or outside of the femur of the patient, to position a tibial component at the inside or outside of the tibia, and to properly position a tibial bearing member between the femoral component and the tibial component, thereby having the effects of improving the range of sense and motion after surgery by preserving other normal joints and reducing blood loss compared to a conventional prosthesis; improving the accuracy of the surgery to prevent the malalignment of the prosthesis, reduce the shaking of the prosthesis and extend the use life of the prosthesis; significantly improving a securing force compared to a conventional prosthesis; and using the knee joint prosthesis for the bi-compartmental knee replacement for patients with bi-compartmental arthritis, genu varum and genu valgum and flexion deformity, and anterior cruciate ligament loss.