Certain embodiments of the present invention provide methods and systems for hanging protocol generation using gesture recognition. Certain embodiments provide a method for creating a hanging protocol based on gesture input in a clinical environment. The method includes specifying a hanging protocol specification using gesture-based input. The method also includes translating the gesture-based input into a hanging protocol. The method further includes facilitating display of clinical information based on the hanging protocol. Certain embodiments provide a gesture detection system. The system includes a sensor surface configured to detect gesture-based input made on the sensor surface. The gesture-based input specifies a hanging protocol layout. The system also includes a processor configured to identify the gesture-based input and translate the gesture to a corresponding hanging protocol definition for display of image and clinical data.