A method of treating or preventing of a disease or condition associated with an increased level of isoforms of amyloid .beta. peptides (A.beta.) and/or with a changed ratio of levels of A.beta. isoforms and/or with the formation of plaques containing amyloid .beta. peptide (A.beta.) isoforms in a mammal comprising administering to said mammal an therapeutically effective amount of a compound selected from the formulas Ia, Ib ##STR00001## wherein V, W, Y, R.sup.2, R.sup.3, R.sup.5, R.sup.6, L1 and i are defined as in claim 1.

 
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> Pharmaceutical/cosmetic compositions comprising novel ligands that activate RAR receptors

~ 00433