A side frame assembly for a wheelchair suspension includes a mainframe, and a front caster frame connected pivotally to both a front end of the mainframe and a front caster. A return spring is disposed between the front caster frame and the mainframe so as to bias the front caster to a predetermined position. A drive wheel assembly includes a drive wheel frame, a drive wheel disposed pivotally on the drive wheel frame, and a driving unit operable to rotate the drive wheel. A linkage is connected pivotally to the mainframe, the front caster frame and the drive wheel frame. A rear caster assembly includes a rear caster frame attached to a rear end of the mainframe, and a rear caster disposed pivotally on the rear caster frame.