Angiogenesis, tumor growth, and metalloproteinase 2 (MMP2) interaction with integrin-.alpha..sub.v.beta..sub.3 are inhibited by an inhibitor compound of formula: ##STR00001## wherein G.sup.1 and G.sup.2 are each independently --NH--C(O)--O--(CH.sub.2).sub.v--(C.sub.6H.sub.4)--X.sup.3 ; Y.sup.1 and Y.sup.2 are each independently --OH or C.sub.1-C.sub.4 alkoxy; X.sup.1 and X.sup.2 are each independently halo or C.sub.1-C.sub.4 alkoxy; X.sup.3 is fluoro, nitro, C.sub.1-C.sub.4 alkyl, C.sub.1-C.sub.4 alkoxy, or C.sub.1-C.sub.4 perfluoroalkyl; Z is --C.ident.C--, --C.sub.6H.sub.4--, cis-CH.dbd.CH--, trans-CH.dbd.CH--, cis-CH.sub.2--CH.dbd.CH--CH.sub.2--, trans-CH.sub.2--CH.dbd.CH--CH.sub.2--, 1,4-naphthyl, cis-1,3-cyclohexyl, trans-1,3-cyclohexyl, cis-1,4-cyclohexyl, or trans-1,4-cyclohexyl; A is H or a covalent bond; m and n are each 1; t is an integer having a value of 0 or 1; p and r are each 2, and v is 1; with the proviso that when A is H, t is 0, and when A is a covalent bond, t is 1.

 
Web www.patentalert.com

< IAP binding compounds

> Three-dimensional in-vitro spinal models and methods of analyzing substance distribution therein

~ 00430