A mattress pad positionable atop a rectangular mattress which better accommodates diverse weights and sizes of the human anatomy for enhanced comfort. The mattress pad includes a flexible bottom sheet having a size and shape substantially similar to that of a top surface of the mattress. A flexible fabric top sheet is connected to the bottom sheet by peripheral stitching along common perimeter side, head and foot margins. A plurality of generally side-by-side body supporting chambers are each defined by peripheral stitching and spaced lines of continuous stitching which interconnect the top and bottom sheets. Each chamber is filled with an open or closed cell urethane foam material. Preselected nominal thicknesses of each of the chambers provides the comfort and accommodation to each portion of the human anatomy.