The present invention is directed to a substituted 4H-chromene represented
by the Formula 1R, substantially free from the corresponding
(S)-stereoisomer:
The present invention also relates to the discovery that compound 1R,
substantially free from the corresponding (S)-stereoisomer, is an
activator of caspases and inducer of apoptosis, as well as an
antivascular agent. Therefore, compound 1R, substantially free from the
corresponding (S)-stereoisomer, can be used to induce cell death in a
variety of clinical conditions in which uncontrolled growth and spread of
abnormal cells occurs. Compound 1R, substantially free from the
corresponding (S)-stereoisomer, also can be used for the treatment of
diseases due to overgrowth of vasculature, such as solid tumors and
ocular neovascularization.