A liquid chromatography/mass spectrometry apparatus combines a
chromatograph having a liquid delivery part for delivering mixed multiple
solvents, and a mass spectrometer having an ionization part for spraying
and ionizing. The apparatus has a storing part for storing a relationship
between a mixture ratio of the multiple solvents in the liquid delivery
part and an optimal or nearly optimal voltage applied to the ionization
part, a ratio information acquiring part for computing the mixture ratio
over time, a voltage value computing part for computing the optimal or
nearly optimal applied voltage at any point, and a voltage controlling
part for changing the voltage applied to the ionization part over time.
By virtue of the ability to adjust the applied voltage during analysis,
the ionization efficiency is always high, and the analysis can be
performed with high sensitivity for all of the multiple components in the
liquid sample.