Anatomical models are provided with simulated plaque, lesion, chronic total occlusion, as well as other vascular diseases that more accurately replicate these abnormalities. In such embodiment, the vascular disease may be formed separate from the structured anatomical model. The formed vascular disease material may then be bonded to or within a PVA material in a separate process from forming this simulated vascular disease, thus providing a replicated specific anatomy structure with an abnormality for demonstrating, testing, and/or developing medical functions and/or devices.