The present invention relates to a method for effecting or maintaining weight loss in an individual in need thereof. The method includes the administration of a weight loss agent in conjunction with a meal replacement formulation. The weight loss agent can be administered separately or co-formulated with the meal replacement agent. The method of the present invention exhibits a beneficial effect wherein the weight loss or weight loss maintenance observed with administration of the weight loss agent with the meal replacement formulation is greater than with the administration of either the weight loss agent or meal replacement formulation alone.