A novel polypeptide binding to SMG-1, a polynucleotide encoding the same, and a system for screening a substance which artificially modifies an MRNA surveillance mechanism, are disclosed. The polypeptide has an activity of binding to SMG-1, an activity of being phosphorylated by SMG-1, and an activity of modifying SMG-1 activities through these activities.

 
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< IN SITU TEST FOR DETERMINING DRUG HISTORY

> METHOD FOR SCREENING TRANSCRIPTIONAL COREGULATORY PROTEINS OF TRANSCRIPTION FACTORS, AND ANDROGEN RECEPTOR TRANSCRIPTIONAL COREGULATORY PROTEINS AS TARGETS FOR ANDROGEN RECEPTOR-DEPENDENT DISEASES

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