The present invention discloses methods of using antagonists for
melanin-concentrating hormone (MCH), to treat obesity, metabolic
disorders, eating disorders such as hyperphagia, and diabetes, as well as
novel compounds which are antagonists for melanin-concentrating hormone
(MCH). In other aspects, the invention is directed to pharmaceutical
compositions comprising such MCH antagonists as well as methods for
preparing such compounds. Compounds of the invention generally have the
structure: ##STR00001## where the substituents are as defined herein.