A medical device introduction system and method can include a medical introducer, a separate imaging device, and/or a separate working channel device, each of which may be movable independent of the other. The medical introducer can include a handle and an elongate introducer tube extending from the handle and having a plurality of lumens, and may be inserted into an interior body region of a patient. The separate imaging device may be inserted through the handle and positioned in one of lumens. The separate working channel device can include an elongate working channel tube and a position controller. The working channel tube can include at least one lumen defining a working channel. The position controller can be configured to control positioning of the working channel tube. The working channel device may be removably connected to the handle and positioned in another lumen.