A process and radiography device for aiding vascular navigation suitable for an area of interest wherein a series of successive images I.sub.n of the region of interest is acquired by a image recording. From the series of images I.sub.n thus acquired a determination is made of a first mask presenting background structures and blood vessels of the region of interest, and a second mask presenting the only background structures. An image I.sub.L is acquired exhibiting at least one instrument introduced into one of the vessels of the region of interest. An image I.sub.v is determined for visualizing by combination of the first and second masks and the image. The image to be visualized thus determined is displayed.