Method and apparatus providing asynchronous neural stimulation pseudo-randomly varying at least one of a plurality of stimulation parameters. Neural stimulation may be monitored and compared with a target. Parameters may be varied to more closely match stimulation target. A range for at least one parameter may be established and the parameter varied within the range. A finite sequence of values within the range may be generated or selected. An average of the finite sequence of values may approximate the stimulation target.

 
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> Use of agomelatine in obtaining medicaments intended for the treatment of smith-magenis syndrome

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