An enhanced heat transfer device with electrodes is provided, which is applied to a heat exchanger with a plurality of fluid channels and includes a plurality of electrodes mounted in the fluid channels of the heat exchanger; a plurality of sensor units mounted in the fluid channels of the heat exchanger for measuring mass flow rates of fluids in the fluid channels; and a power source for providing voltage to the electrodes. The power source is used to drive the electrodes to produce turbulence to fluids passing through the fluid channels according to measured mass flow rates from the sensor units, so as to facilitate uniform fluid flows in the plurality of fluid channels and reduce effect of thermal boundary layer in the fluid channels to thereby enhance heat transfer performance for the heat exchanger.