Compounds of formula (I) ##STR00001## are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity, wherein X.sub.1, X.sub.2, X.sub.3, X.sub.4, X.sub.5, R.sub.5, R.sub.6, R.sub.7, R.sub.8a, R.sub.8b, R.sub.9, Z.sub.1, Z.sub.2, and L are defined in the description.

 
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