A wireless Universal Serial Bus (USB) device enumerates one or more real or virtual hubs that support transmission of USB data over a wireless network. The number of virtual hubs presented to a USB host can be varied dynamically according to monitored characteristics of the wireless network, such as the propagation delay, Bit Error Rate, or USB configuration of the peripheral device. Another aspect of the wireless system varies a USB transmission rate according to the amount of bandwidth available on the wireless network.