Disclosed are methods, systems, and/or processor program products that include generating a population of genotypes, the genotypes based on at least one stimulus to a system, measuring at least one response of the system upon providing the population of genotypes to at least one model of the system, and, based on the measured at least one response of the system, performing at least one of: (a) applying at least one genetic operator to at least some of the population of genotypes, and iteratively returning to generating a population of genotypes, and (b) associating a condition of the system with at least one of the population of genotypes.