A dental floss holder including: a base portion; a pair of spaced-apart jaws extending from the base portion to accommodate a length of dental floss there-between; the spaced-apart jaws having at least one cavity for loading a composition containing flavor and/or a chemotherapeutic agent; and at least one flange for each cavity is disclosed. The dental floss holder provides an improved means for retaining flavor and or chemotherapeutic compositions within the cavity until the dental floss holder is used.