It has been surprisingly found that ZAP-70 expression, both at the protein and mRNA levels, is indicative of clinical subgroups of CLL/SLL patients. In particular, high ZAP-70 expression is indicative of Ig-unmutated CLL/SLL. Methods are provided for discriminating between clinical subgroups of CLL/SLL, by determining whether subjects overexpress ZAP-70 mRNA mRNA or protein.

 
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< Slab laser and method with improved and directionally homogenized beam quality

> Method of treatment of hemorrhagic disease using a factor VIIa/tissue factor inhibitor

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