A method and apparatus for providing a radiation hardened Phase Locked Loop (PLL) are presented. The radiation hardened PLL includes an adjustable bandwidth loop filter. The adjustable filter modifies an unfiltered voltage control signal and provides a stable voltage control signal to a Voltage Controlled Oscillator (VCO) during detected radiation induced transient events. The adjustable filter filters out radiation effects by decreasing its bandwidth when a radiation event is detected.

 
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> Detection of extracellular tumor-associated nucleic acid in blood plasma or serum using nucleic acid amplification assay

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