An apparatus, device, methods, computer program product, and system are described that receive a request for a treatment option, the request associated with at least one query parameter, determine at least one treatment parameter, based on the request, the at least one treatment parameter including at least one target-related tissue ancestry-correlated binding site and/or at least one target-related tissue ancestry-correlated binding agent, and provide the treatment option, based on the at least one treatment parameter and the at least one query parameter.