The invention provides enantiomers of ajoene and derivatives of Z(-)-ajoene. The derivative of Z(-)-ajoene are useful for modulating integrin-mediated functions, for treating disorders, diseases or conditions in which integrins play a role, and for treating tissues to improve their condition for a subsequent use, such as transplantation.

 
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> Binding assay employing IGS4, a human G-protein coupled neuromedin receptor

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