An advanced technology screening checkpoint system includes a baggage screening zone, a passenger screening zone, and a secondary screening zone. The baggage screening zone may include an explosives scanning system and an imaging system, while the passenger screening zone may include an explosives detection portal and a self-divestment portal to show passengers what to divest prior to screening by a high sensitivity metal detection portal. In some implementations, a secondary screening zone includes a sealed-bottle scanning system, an enhanced explosives detection system, a weapons search routine, and a body scanning system. Centralized monitoring of screening results for individual detection and screening systems of the baggage, passenger, and secondary screening zones may be provided by a combined user interface (CUI).