The present invention can be used for actual implantation surgery without
a scaffold. The present invention provides a synthetic tissue or complex
which can be produced by culture and has a high level of differentiation
ability. The present invention also provides a therapy and medicament for
repairing and/or regenerating tissue using replacement and covering. By
culturing cells under specific culture conditions such that medium
contains an extracellular matrix synthesis promoting agent, the cells are
organized and are easily detached from a culture dish. The present
invention was achieved by finding such a phenomenon. In addition, the
self contraction of the tissue can be regulated by culturing the tissue
in a suspended manner. Therefore, it is possible to regulate the
three-dimensional shape of the tissue. The present invention also
provides a method for producing an implantable synthetic tissue which
does not require a plurality of monolayer cell sheets assembled to form a
three-dimensionally structured synthetic tissue. The present invention is
characterized by richness in adhesion molecules, nonnecessity of
additional fixation at an implantation site, and good biological
integration.