Histone deacetylase is a metallo-enzyme with zinc at the active site. Compounds having a zinc-binding moiety, such as, for example, a hydroxamic acid group or a carboxylic acid group, can inhibit histone deacetylase. Histone deacetylase inhibition can repress gene expression, including expression of genes related to tumor suppression. Accordingly, inhibition of histone deacetylase can provide an alternate route for treating cancer, hematological disorders, e.g., hemoglobinopathies, and genetic related metabolic disorders, e.g., cystic fibrosis and adrenoleukodystrophy.

 
Web www.patentalert.com

< Diamine derivatives, process for producing the diamine derivatives, and fungicides containing the diamine derivatives as an active ingredient

> Control of parasites in animals by the use of novel trifluoromethanesulfonanilide oxime ether derivatives

~ 00400