The present invention relates to compounds of the Formula: ##STR00001## wherein R.sup.1 to R.sup.6, X, Z and A are as defined. These compounds have activity inhibiting production of A.beta.-peptide. The invention also relates to pharmaceutical compositions and methods for treating diseases, for example, neurodegenerative diseases, e.g., Alzheimer's disease, in a mammal comprising compounds of the present Formula.

 
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> Smilagenin and its use

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